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In vitro assessment of edoxaban anticoagulant effect in pediatric plasma.

著者 Sinegre T , Zlobecki M , Doré E , Pereira B , Grèze V , Lebreton A
Thromb Res.2019 Apr 13 ; 178():112-118.
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Anticoagulant therapy in pediatric patients remains an issue and safer therapies, such as direct oral anticoagulants could overcome the limitations of conventional anticoagulant treatments in this population. Edoxaban, a factor Xa inhibitor, is used for the prevention and treatment of venous thromboembolism. Due to its pharmacokinetic characteristics, edoxaban is a promising candidate molecule for children. This study compared edoxaban in vitro effect in children and adults.
PMID: 31005667 [PubMed - as supplied by publisher]
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