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M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model.

著者 Roy S , Nanovskaya T , Patrikeeva S , Cochran E , Parge V , Guess J , Schaeck J , Choudhury A , Ahmed M , Ling LE
Am J Obstet Gynecol.2019 Mar 05 ; ():.
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The transfer of pathogenic immunoglobulin G antibodies from mother to fetus is a critical step in the pathophysiology of alloimmune and autoimmune diseases of the fetus and neonate. Immunoglobulin G transfer across the human placenta to the fetus is mediated by the neonatal Fc receptor, and blockade of the neonatal Fc receptor may provide a therapeutic strategy to prevent or minimize pathological events associated with immune-mediated diseases of pregnancy. M281 is a fully human, aglycosylated monoclonal immunoglobulin G1 anti-neonatal Fc receptor antibody that has been shown to block the neonatal Fc receptor with high affinity in nonclinical studies and in a phase 1 study in healthy volunteers.
PMID: 30849355 [PubMed - as supplied by publisher]
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