絞り込み

16599

広告

Clonal approaches to understanding the impact of mutations on hematologic disease development.

著者 Nangalia J , Mitchell E , Green AR
Blood.2019 Feb 06 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (3view , 0users)

Full Text Sources

Interrogation of hematopoietic tissue at the clonal level has a rich history spanning over 50 years, and has provided critical insights into both normal and malignant hematopoiesis. Characterization of chromosomes identified some of the first genetic links to cancer with the discovery of chromosomal translocations in association with many hematological neoplasms. The unique accessibility of hematopoietic tissue and the ability to clonally expand hematopoietic progenitors in vitro has provided fundamental insights into the cellular hierarchy of normal hematopoiesis, as well as the functional impact of driver mutations in disease. Transplantation assays in murine models have enabled cellular assessment of the functional consequences of somatic mutations in vivo. Most recently, next-generation sequencing based assays have shown great promise in allowing multi 'omic' characterisation of single cells. Here we review how clonal approaches have advanced our understanding of disease development, focussing on the acquisition of somatic mutations, clonal selection, driver mutation cooperation and tumor evolution.
PMID: 30728143 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード