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Catalytic α-Selective Deuteration of Styrene Derivatives.

著者 Puleo TR , Strong AJ , Bandar JS
J Am Chem Soc.2019 Jan 09 ; ():.
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We report an operationally simple protocol for the catalytic α-deuteration of styrenes. This process proceeds via the base-catalyzed reversible addition of methanol to styrenes in DMSO- d solvent. The concentration of methanol is shown to be critical for high yields and selectivities over multiple competing side reactions. The synthetic utility of α-deuterated styrenes for accessing deuterium-labeled chiral benzylic stereocenters is demonstrated.
PMID: 30625273 [PubMed - as supplied by publisher]
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