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Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral β-Amino Acids via Trapping of an Enol Intermediate.

著者 Kang Z , Wang Y , Zhang D , Wu R , Xu X , Hu W
J Am Chem Soc.2019 Jan 09 ; ():.
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A novel enantioselective aminomethylation reaction of diazo compound, alcohol and α-aminomethyl ether enabled by asymmetric counter-anion-directed catalysis (ACDC) is disclosed that offers an efficient and convenient access to furnish optically active α-hydroxyl-β-amino acids in high yield with high to excellent enantioselectivities. Control experiments and DFT calculations indicate that the transformation proceeds through trapping the in situ generated enol intermediate with methylene iminium ion, and the asymmetric induction was enabled by chiral pentacarboxycyclopentadiene (PCCP) anion via H-bonding and electrostatic interaction.
PMID: 30624920 [PubMed - as supplied by publisher]
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