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Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma.

著者 Loriguet L , Morisse MC , Dremaux J , Collet L , Attencourt C , Coutte A , Boone M , Sevestre H , Galmiche A , Gubler B , Chauffert B , Trudel S
BMC Cancer.2018 Oct 11 ; 18(1):964.
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Epidermal growth factor receptor (EGFR) gene alterations and amplification are frequently reported in cases of glioblastoma (GBM). However, EGFR-activating mutations that confer proven sensitivity to tyrosine kinase inhibitors (TKIs) in lung cancer have not yet been reported in GBM.
PMID: 30305059 [PubMed - in process]
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