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A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy.

著者 Rao LM , Hussain SA , Zaki T , Cho A , Chanlaw T , Garg M , Sankar R
Epilepsy Behav.2018 Oct 05 ; 88():212-217.
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Seizures are common in term infants with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia. Although phenobarbital (PHB) is generally considered first-line therapy, some centers have embraced third-generation antiepileptic drugs (AEDs) such as levetiracetam (LEV) given the impression of comparable efficacy and superior tolerability. We set out to compare the efficacy of PHB and LEV in a large single-center cohort.
PMID: 30296665 [PubMed - as supplied by publisher]
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