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Distributions of low attenuation areas in 2D CT lung slices are used to quantify parenchymal destruction in patients with COPD. However, these segmental approaches are limited and may not reflect the true 3D tissue processes that drive emphysematous changes in the lung. The goal of this study was to instead evaluate distributions of 3D low-attenuation volumes, which we hypothesized would follow a power law distribution and provide a more complete assessment of the mechanisms underlying disease progression.
PMID: 30292758 [PubMed - as supplied by publisher]