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The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure.

著者 Waldschmitt N , Kitamoto S , Secher T , Zacharioudaki V , Boulard O , Floquet E , Delacre M , Lamas B , Pham HP , Six A , Richard ML , Dagorn JC , Eberl G , Langella P , Chatel JM , Ryffel B , Iovanna JL , Poulin LF , Sokol H , Kamada N , Chamaillard M
Gut.2018 Oct 02 ; ():.
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Loss of the Crohn's disease predisposing gene results in an intestinal microenvironment conducive for colonisation by attaching-and-effacing enteropathogens. However, it remains elusive whether it relies on the intracellular recruitment of the serine-threonine kinase RIPK2 by NOD2, a step that is required for its activation of the transcription factor NF-κB.
PMID: 30279238 [PubMed - as supplied by publisher]
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