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The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

著者 Vasconez AE , Janetzko P , Oo JA , Pflüger-Müller B , Ratiu C , Gu L , Helin K , Geisslinger G , Fleming I , Schröder K , Fork C , Brandes RP , Leisegang MS
Acta Physiol (Oxf).2018 Aug 04 ; ():e13168.
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The histone demethylase Jarid1b limits gene expression by removing the active methyl-mark from histone3-lysine4 at gene promoter regions. A vascular function of Jarid1b is unknown, but a vasoprotective function to inflammatory and hypertrophic stimuli, like Angiotensin II (AngII) could be inferred. This hypothesis was tested using Jarid1b knockout mice and the inhibitor PBIT.
PMID: 30076673 [PubMed - as supplied by publisher]
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