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Systematic approach demonstrates enrichment of multiple interactions between non- risk variants and risk alleles in rheumatoid arthritis.

著者 Diaz-Gallo LM , Ramsköld D , Shchetynsky K , Folkersen L , Chemin K , Brynedal B , Uebe S , Okada Y , Alfredsson L , Klareskog L , Padyukov L
Ann Rheum Dis.2018 Jul 02 ; ():.
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In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), a particular subset of alleles, called shared epitope (SE) alleles, is a highly influential genetic risk factor. Here, we investigated whether non- single nucleotide polymorphisms (SNP), conferring low disease risk on their own, interact with SE alleles more frequently than expected by chance and if such genetic interactions influence the SE effect concerning risk to ACPA-positive RA.
PMID: 29967194 [PubMed - as supplied by publisher]
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