Systematic approach demonstrates enrichment of multiple interactions between non- risk variants and risk alleles in rheumatoid arthritis.
Diaz-Gallo LM , Ramsköld D , Shchetynsky K , Folkersen L , Chemin K , Brynedal B , Uebe S , Okada Y , Alfredsson L , Klareskog L , Padyukov L 
Ann Rheum Dis.2018 Jul 02 ; ():.
PubMedで表示
Google翻訳で開く
(10view , 0users)
Full Text Sources
In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), a particular subset of alleles, called shared epitope (SE) alleles, is a highly influential genetic risk factor. Here, we investigated whether non- single nucleotide polymorphisms (SNP), conferring low disease risk on their own, interact with SE alleles more frequently than expected by chance and if such genetic interactions influence the SE effect concerning risk to ACPA-positive RA.
PMID: 29967194 [PubMed - as supplied by publisher]
PMID: 29967194 [PubMed - as supplied by publisher]
関連論文
- Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
- Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis.
- Smoking interacts with HLA-DRB1 shared epitope in the development of ACPA-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA).
- [Review] Genetics of Rheumatoid Arthritis - A Comprehensive Review.
- Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA.