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Genomic / mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis.

著者 Li M , Liu F , Zhang F , Zhou W , Jiang X , Yang Y , Qu K , Wang Y , Ma Q , Wang T , Bai L , Wang Z , Song X , Zhu Y , Yuan R , Gao Y , Liu Y , Jin Y , Li H , Xiang S , Ye Y , Zhang Y , Jiang L , Hu Y , Hao Y , Lu W , Chen S , Gu J , Zhou J , Gong W , Zha
Gut.2018 Jun 28 ; ():.
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Patients with gallbladder carcinoma (GBC) lack effective treatment methods largely due to the inadequacy of both molecular characterisation and potential therapeutic targets. We previously uncovered a spectrum of genomic alterations and identified recurrent mutations in the ErbB pathway in GBC. Here, we aimed to study recurrent mutations of genes and pathways in a larger cohort of patients with GBC and investigate the potential mechanisms and clinical significance of these mutations.
PMID: 29954840 [PubMed - as supplied by publisher]
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