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Apoptosis-derived membrane vesicles drive the cGAS-STING pathway and enhance type I IFN production in systemic lupus erythematosus.

著者 Kato Y , Park J , Takamatsu H , Konaka H , Aoki W , Aburaya S , Ueda M , Nishide M , Koyama S , Hayama Y , Kinehara Y , Hirano T , Shima Y , Narazaki M , Kumanogoh A
Ann Rheum Dis.2018 Jun 26 ; ():.
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Despite the importance of type I interferon (IFN-I) in systemic lupus erythematosus (SLE) pathogenesis, the mechanisms of IFN-I production have not been fully elucidated. Recognition of nucleic acids by DNA sensors induces IFN-I and interferon-stimulated genes (ISGs), but the involvement of cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) and stimulator of interferon genes (STING) in SLE remains unclear. We studied the role of the cGAS-STING pathway in the IFN-I-producing cascade driven by SLE serum.
PMID: 29945921 [PubMed - as supplied by publisher]
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