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Effects of valproate on reproductive endocrine function in male patients with epilepsy: A systematic review and meta-analysis.

著者 Zhao S , Wang X , Wang Y , Xu J , Zhu G , Zhao C , Teng W
Epilepsy Behav.2018 Jun 22 ; 85():120-128.
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Valproate (VPA) is a broad spectrum antiepileptic drug (AED) that is generally used as a first line agent for most idiopathic and symptomatic generalized epilepsies. Many studies have indicated that AEDs cause reproductive endocrine disorders in males, but the exact etiology underpinning these dysfunctions is not clear. This meta-analysis and systematic review was intended to evaluate the effect of VPA on reproductive endocrine function in male patients with epilepsy.
PMID: 29940375 [PubMed - as supplied by publisher]
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