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Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose denosumab in healthy Chinese volunteers: A randomized, single-blind, placebo-controlled study.

著者 Chen Q , Hu C , Liu Y , Song R , Zhu W , Zhao H , Nino A , Zhang F , Liu Y
PLoS One.2018 ; 13(6):e0197984.
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Denosumab is a fully human monoclonal antibody against receptor activator of nuclear factor kappa-B ligand, a cytokine essential for the formation, function and survival of osteoclasts. This study assessed the pharmacokinetics, pharmacodynamics, safety and tolerability of single-dose denosumab (60 and 120 mg) in healthy Chinese volunteers.
PMID: 29933364 [PubMed - in process]
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