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Number of individual ACPA reactivities in synovial fluid immune complexes, but not serum anti-CCP2 levels, associate with inflammation and joint destruction in rheumatoid arthritis.

著者 Sohrabian A , Mathsson-Alm L , Hansson M , Knight A , Lysholm J , Cornillet M , Skriner K , Serre G , Larsson A , Weitoft T , Rönnelid J
Ann Rheum Dis.2018 Jun 12 ; ():.
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Individual patients with rheumatoid arthritis (RA) show divergent specific anti-citrullinated protein/peptide antibodies (ACPA) patterns, but hitherto no individual ACPA specificity has consistently been linked to RA pathogenesis. ACPA are also implicated in immune complexes (IC)-associated joint pathology, but until now, there has been no method to investigate the role of individual ACPA in RA IC formation and IC-associated pathogenesis.
PMID: 29895567 [PubMed - as supplied by publisher]
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