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CLINICIAN'S CAPSULE What is known about the topic? Most children who sustain a concussion suffer from post-concussion symptoms for many weeks following the accident. What did this study ask? Is there an association between ondansetron administration and the presence of persistent post-concussion symptoms at 1 week and 1 month in children? What did this study find? This observational study found that the use of ondansetron among children presenting to the emergency department with an acute concussion was associated with a higher risk of persistent symptoms at 1 month. Why does this study matter to clinicians? The treatment of short-term symptoms of a concussion should be balanced with the potential long-term harm of ondansetron.
PMID: 29877168 [PubMed - as supplied by publisher]