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The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice.

著者 Olivares M , Neyrinck AM , Pötgens SA , Beaumont M , Salazar N , Cani PD , Bindels LB , Delzenne NM
Diabetologia.2018 May 25 ; ():.
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Dipeptidyl peptidase 4 (DPP-4) inhibitors are agents designed to increase the half-life of incretins. Although they are administered orally, little is known about their effects on the gut microbiota and functions, despite the fact that some bacteria present in the gut microbiota exhibit DPP-4-like activity. Our objective was to study the impact of the DPP-4 inhibitor vildagliptin on gut functions and the intestinal ecosystem in a murine model of obesity induced by a Western diet (WD).
PMID: 29797022 [PubMed - as supplied by publisher]
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