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アカウミガメ 人工繁殖で3世代目が誕生 和歌山 串本町 (NHK)

アカウミガメの繁殖に取り組んでいる和歌山県串本町の水族館で、人が飼育する環境で3世代目の繁殖に成功しました。水族館によりますと世界で初めてだということです。 串...

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  2. 医療の本音:和を尊び脱コロナへ=松本尚(...
  3. 新型コロナ 中国新車販売、回復鮮明 日米...
  4. いきものと生きる:宮古島のヒラタクワガタ...

ニュース一覧

Mesalazine (5-ASA) is an aminosalicylate anti-inflammatory drug capable of inducing μ-protocadherin, a protein expressed by colorectal epithelial cells which is downregulated upon malignant transformation. Treatment with 5-ASA restores μ-protocadherin expression and promotes the sequestration of β-catenin to the plasma membrane. Here we show that 5-ASA-induced μ-protocadherin expression is directly regulated by the KLF4 transcription factor. In addition, we suggest the existence of a dual mechanism whereby 5-ASA-mediated β-catenin inhibition is caused by μ-protocadherin-dependent sequestration of β-catenin to the plasma membrane and by the direct binding of KLF4 to β-catenin. In addition, we found that 5-ASA treatment suppresses the expression of miR-130a and miR-135b, which target KLF4 mRNA, raising the possibility that this mechanism is involved in the increased expression of KLF4 induced by 5-ASA.
PMID: 29794245 [PubMed - as supplied by publisher]
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