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Toll-Like Receptor 3 Signaling Contributes to Regional Neutrophil Recruitment in Cultured Human Glomerular Endothelial Cells.

著者 Liu Q , Imaizumi T , Kawaguchi S , Aizawa T , Matsumiya T , Watanabe S , Tsugawa K , Yoshida H , Tsuruga K , Joh K , Kijima H , Tanaka H
Nephron.2018 May 23 ; ():1-10.
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Given the importance of neutrophil recruitment in the pathogenesis of glomerulonephritis (GN), the representative neutrophil chemoattractant C-X-C motif chemokine 1 (CXCL1)/GROα and the adhesion molecule E-selectin in glomerular endothelial cells (GECs) play a pivotal role in the development of GN. Endothelial Toll-like receptor 3 (TLR3) is thought to be involved in the inflammatory response via innate immunity. However, the role of endothelial TLR3 signaling in the expression of neutrophil chemoattractants and adhesion molecules remains to be elucidated. Thus, we aimed to examine this issue.
PMID: 29791907 [PubMed - as supplied by publisher]
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