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Pre-exposure to Fluorouracil Increased Trifluridine Incorporation and Enhanced its Anti-tumor Effect for Colorectal Cancer.

著者 Baba T , Kokuryo T , Yamaguchi J , Yokoyama Y , Uehara K , Ebata T , Nagino M
Anticancer Res.2018 Mar ; 38(3):1427-1434.
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Trifluridine/tipiracil (FTD/TPI) is used for metastatic colorectal cancer, that is refractory to 5-fluorouracil (5-FU)-based therapies. However, the impact of pre-exposure to 5-FU on the anti-cancer effect of FTD, which is a key component of FTD/TPI, is unclear.
PMID: 29491068 [PubMed - in process]
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