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Defective WNT signaling associates with bone marrow fibrosis-a cross-sectional cohort study in a family with WNT1 osteoporosis.

著者 Mäkitie RE , Niinimäki R , Kakko S , Honkanen T , Kovanen PE , Mäkitie O
Osteoporos Int.2017 Nov 16 ; ():.
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This study explores bone marrow function in patients with defective WNT1 signaling. Bone marrow samples showed increased reticulin and altered granulopoiesis while overall hematopoiesis was normal. Findings did not associate with severity of osteoporosis. These observations provide new insight into the role of WNT signaling in bone marrow homeostasis.
PMID: 29147753 [PubMed - as supplied by publisher]
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