絞り込み

16421

広告

不安払しょく 被ばく量試算できるアプリ開発へ (NHK)

原発事故で避難している人たちのうち、帰還を考えている人などの不安を少しでも払拭(ふっしょく)しようと原子力規制委員会は、福島県内での生活パターンを踏まえて被ばく...

  1. トランプ政権1年 深刻な国際秩序の「漂流...
  2. 着物 タンスに眠らせず 京都大(キャンパ...
  3. 遺体は蓮ちゃん、DNA鑑定で断定 - 福...
  4. 物質のナノレベル解析に光 次世代放射光施...

ニュース一覧

Cardioprotection of dapagliflozin and vildagliptin in cardiac reperfusion injury rats.

著者 Tanajak P , Sa-Nguanmoo P , Sivasinprasan S , Thummasorn S , Siri-Angkul N , Chattipakorn S , Chattipakorn N
J Endocrinol.2017 Nov 15 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (43view , 0users)

Full Text Sources

Miscellaneous

Sodium-glucose cotransporter 2 inhibitor (SGLT2-i) effects on cardiac ischemia/reperfusion (I/R) injury are unclear. Unlike SGLT2-i, dipeptidyl peptidase 4 inhibitors (DPP4-i) have shown effective cardioprotection in cardiac I/R injury. We aimed to investigate whether SGLT2-i reduces myocardial dysfunction and myocardial injury to a greater extent than DPP4-i in obese-insulin resistant rats with/without cardiac I/R injury. The high fat (HF) diet induced obese-insulin resistant rats were divided into 4 groups and received the following treatments for 28 days: vehicle (HFV); vildagliptin at a dosage of 3 mg/kg/day (HFVil); dapagliflozin at a dosage of 1 mg/kg/day (HFDa); and combination drugs (HFDaVil). At the end, I/R injury was induced by a 30-minute left anterior descending coronary occlusion and 120-minute reperfusion. Dapagliflozin showed a greater efficacy than vildagliptin in improving the metabolic impairments, low frequency/high frequency (LF/HF) ratio, systolic blood pressure and left ventricular (LV) function in comparison to HFV rats. In cardiac I/R injury, Dapagliflozin had a greater efficacy than vildagiptin in decreasing mitochondrial DRP1, cleaved caspase 3, LV dysfunction and infarct size in comparison to HFV rats. However, the combined therapy showed the greatest efficacy in attenuating LV dysfunction, mitochondrial DRP1 and infarct size in comparison to HFV rats. In conclusion, dapagliflozin has a more pronounced effect than vildagliptin in obese-insulin resistant rats for the improvement of LV function. In rats with cardiac I/R injury, although dapagliflozin had a greater efficacy on cardioprotection than vildagliptin, the combined therapy exerted the highest cardioprotective effects potentially through reducing mitochondrial fission.
PMID: 29142025 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード