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Preventive effect of kampo medicine (hangeshashin-to, TJ-14) plus minocycline against afatinib-induced diarrhea and skin rash in patients with non-small cell lung cancer.

著者 Ichiki M , Wataya H , Yamada K , Tsuruta N , Takeoka H , Okayama Y , Sasaki J , Hoshino T
Onco Targets Ther.2017 ; 10():5107-5113.
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Diarrhea and oral mucositis induced by afatinib can cause devastating quality of life issues for patients undergoing afatinib treatment. Several studies have shown that hangeshashin-to (TJ-14) might be useful for chemotherapy-induced diarrhea and oral mucositis. In this study, we investigated the prophylactic effects of TJ-14 for afatinib-induced diarrhea and oral mucositis and minocycline for afatinib-induced skin rash.
PMID: 29123409 [PubMed]
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