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d-Leucine: Evaluation in an epilepsy model.

著者 Holden K , Hartman AL
Epilepsy Behav.2017 Nov 07 ; ():.
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Current medicines do not provide sufficient seizure control for nearly one-third of patients with epilepsy. New options are needed to address this treatment gap. We recently found that the atypical amino acid d-leucine protected against acutely-induced seizures in mice, but its effect in chronic seizures has not been explored. We hypothesized that d-leucine would protect against spontaneous recurrent seizures. We also investigated whether mice lacking a previously-described d-leucine receptor (Tas1R2/R3) would be protected against acutely-induced seizures.
PMID: 29122492 [PubMed - as supplied by publisher]
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