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国内最大サンゴ礁、生息6割減…海水温上昇で (読売新聞)

石西礁湖で昨年、白化した状態で見つかったサンゴ=環境省提供 環境省は19日、沖縄や九州、四国など日本近海にあるサンゴ礁について、今年度の調査結果を発表した。 調...

  1. 国内最大サンゴ礁、生息6割減…海水温上昇...
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  4. 文部科学省初等中等教育局非常勤職員(時間...

ニュース一覧

Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expressed in primary lung tumors, an active RANK pathway correlates with decreased survival, and pharmacologic RANK inhibition reduces tumor growth in patient-derived lung cancer xenografts. Clonal genetic inactivation of KRas(G12D) in mouse lung epithelial cells markedly impairs the progression of KRas(G12D) -driven lung cancer, resulting in a significant survival advantage. Mechanistically, RANK rewires energy homeostasis in human and murine lung cancer cells and promotes expansion of lung cancer stem-like cells, which is blocked by inhibiting mitochondrial respiration. Our data also indicate survival differences in KRas(G12D) -driven lung cancer between male and female mice, and we show that female sex hormones can promote lung cancer progression via the RANK pathway. These data uncover a direct role for RANK in lung cancer and may explain why female sex hormones accelerate lung cancer development. Inhibition of RANK using the approved drug denosumab may be a therapeutic drug candidate for primary lung cancer.
PMID: 29118048 [PubMed - as supplied by publisher]
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