絞り込み

16555

広告

職員以外も加算 ケアマネなど、処遇改善 (毎日新聞)

厚生労働省は15日、来年10月の消費増税に合わせた介護職員の処遇改善策について、介護報酬の加算分を介護職員以外の職種の給与増に使うことを認める方針を示した。対象...

  1. 温暖化でビール高値に 大麦の収穫減で -...
  2. 温暖化でビール高値に - 徳島新聞
  3. 温暖化でビール高値に (デイリースポーツ...
  4. 温暖化でビール高値に 大麦の収穫減、今世...

ニュース一覧

Glucocorticoid exposure induces preeclampsia via dampening 1,25-dihydroxyvitamin D3.

著者 Zhang D , Zeng J , Miao X , Liu H , Ge L , Huang W , Jiao J , Ye D
Hypertens Res.2017 Nov 02 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (48view , 0users)

Full Text Sources

The pathogenesis of preeclampsia (PE) involves a number of biological processes that may be directly or indirectly affected by glucocorticoid (GC) and vitamin D. GC exposure increases the risk of PE, and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) deficiency may result in PE. The purpose of the present study was to confirm the involvement of GC/1,25-(OH)2D3 axis in the pathogenesis of PE. In the study, cortisol levels of PE patients were found to be higher than that of non-complicated pregnancies, while 1,25-(OH)2D3 were decreased in both PE women and GC-induced PE rats. Mechanically, GC reduced 1,25-(OH)2D3 levels via disturbing its biosynthetic and catabolic enzymes, including Cyp3a1,Cyp24a1 and Cyp27b1, especially enhancing the expressions of Cyp3a1, the dominant enzyme for vitamin D degeneration. Moreover, replenishing 1,25-(OH)2D3 ameliorated the symptoms and placental oxidative stress of GC-induced rat PE. The protective actions of 1,25-(OH)2D3 might be explained by its roles in antagonizing the effects of GC on trophoblast proliferation and apoptosis. Together, these findings suggest that GC exposure could lead to PE via dampening 1,25-(OH)2D3 biosynthesis, and GC/1,25-(OH)2D3 axis might represent a common pathway through which PE occurs.Hypertension Research advance online publication, 2 November 2017; doi:10.1038/hr.2017.98.
PMID: 29093562 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード