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Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling.

著者 Javary J , Allain-Courtois N , Saucisse N , Costet P , Heraud C , Benhamed F , Pierre R , Bure C , Pallares-Lupon N , Do Cruzeiro M , Postic C , Cota D , Dubus P , Rosenbaum J , Benhamouche-Trouillet S
Gut.2017 Oct 26 ; ():.
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The AAA+ ATPase Reptin is overexpressed in hepatocellular carcinoma and preclinical studies indicate that it could be a relevant therapeutic target. However, its physiological and pathophysiological roles in vivo remain unknown. This study aimed to determine the role of Reptin in mammalian adult liver.
PMID: 29074727 [PubMed - as supplied by publisher]
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