絞り込み

16525

広告

珍しい中型ティラノサウルス類の骨?…北海道 (読売新聞)

北海道大学は20日、北海道芦別市の白亜紀後期(約1億年~約6600万年前)の地層から見つかった恐竜の化石が、ティラノサウルス類の尾の骨である可能性が高いことが分...

  1. なぜ博士キャラは「〜じゃ」と話すの?リア...
  2. 【書評】中国のSF作家はどれだけ未来を見...
  3. エタノールから酢酸 合成方法を開発 (毎...
  4. DNAで恋が芽生える!新時代の婚活サービ...

ニュース一覧

Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease.

著者 Stojkovska I , Krainc D , Mazzulli JR
Cell Tissue Res.2017 Oct 24 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (51view , 0users)

Full Text Sources

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized pathologically by the presence of Lewy bodies comprised of insoluble alpha (α)-synuclein. Pathological, clinical and genetic studies demonstrate that mutations in the GBA1 gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase) that is deficient in Gaucher's disease, are important risk factors for the development of PD. The molecular mechanism for the association between these two diseases is not completely understood. We discuss several possible mechanisms that may lead to GBA1-related neuronal death and α-synuclein accumulation including disruptions in lipid metabolism, protein trafficking and impaired protein quality control mechanisms. Elucidating the mechanism between GCase and α-synuclein may provide insight into potential therapeutic pathways for PD and related synucleinopathies.
PMID: 29064079 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード