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アカウミガメ 人工繁殖で3世代目が誕生 和歌山 串本町 (NHK)

アカウミガメの繁殖に取り組んでいる和歌山県串本町の水族館で、人が飼育する環境で3世代目の繁殖に成功しました。水族館によりますと世界で初めてだということです。 串...

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IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

著者 Lee CH , Romain G , Yan W , Watanabe M , Charab W , Todorova B , Lee J , Triplett K , Donkor M , Lungu OI , Lux A , Marshall N , Lindorfer MA , Goff OR , Balbino B , Kang TH , Tanno H , Delidakis G , Alford C , Taylor RP , Nimmerjahn F , Varadarajan N , B
Nat Immunol.2017 Jun 12 ; ():.
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Engineered crystallizable fragment (Fc) regions of antibody domains, which assume a unique and unprecedented asymmetric structure within the homodimeric Fc polypeptide, enable completely selective binding to the complement component C1q and activation of complement via the classical pathway without any concomitant engagement of the Fcγ receptor (FcγR). We used the engineered Fc domains to demonstrate in vitro and in mouse models that for therapeutic antibodies, complement-dependent cell-mediated cytotoxicity (CDCC) and complement-dependent cell-mediated phagocytosis (CDCP) by immunological effector molecules mediated the clearance of target cells with kinetics and efficacy comparable to those of the FcγR-dependent effector functions that are much better studied, while they circumvented certain adverse reactions associated with FcγR engagement. Collectively, our data highlight the importance of CDCC and CDCP in monoclonal-antibody function and provide an experimental approach for delineating the effect of complement-dependent effector-cell engagement in various therapeutic settings.
PMID: 28604720 [PubMed - as supplied by publisher]
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