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Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.

著者 Lefebure M , Tothill RW , Kruse E , Hawkins ED , Shortt J , Matthews GM , Gregory GP , Martin BP , Kelly MJ , Todorovski I , Doyle MA , Lupat R , Li J , Schroeder J , Wall M , Craig S , Poortinga G , Cameron D , Bywater M , Kats L , Gearhart MD , Bardwell
Nat Commun.2017 Mar 06 ; 8():14581.
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The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.
PMID: 28262675 [PubMed - in process]
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