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Differential Expression of CD52, CD14 and HLA-DR on CD4+ Monocytes in Three Types of Acquired Bone Marrow Failure Syndromes.

著者 Kai Y , Yuanyuan D , Shihe G , Xuanxuan M , Hao Z , Ying P , Yuanyuan W , Aihua W , Beibei S , , Tingdong Z
Clin Lab.2016 Sep 01 ; 62(9):1767-1772.
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Aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH), and myelodysplastic syndrome (MDS) are the common spectrums of acquired bone marrow failure syndromes (BMFs). Accurate and timely diagnosis is a significant clinical challenge because of the overlapping features. The pathogenesis is not fully understood, but several studies have suggested that defective monocyte functions play an important role. We aimed to find whether the different expressions of CD52, CD14 and HLA-DR on CD4+ monocytes would be helpful in the preliminary diagnosis of acquired BMFs.
PMID: 28164595 [PubMed - in process]
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