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PET imaging of (64)Cu-DOTA-scFv-anti-PSMA lipid nanoparticles (LNPs): Enhanced tumor targeting over anti-PSMA scFv or untargeted LNPs.

著者 Wong P , Li L , Chea J , Delgado MK , Crow D , Poku E , Szpikowska B , Bowles N , Channappa D , Colcher D , Wong JY , Shively JE , Yazaki PJ
Nucl Med Biol.2017 Jan 17 ; 47():62-68.
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Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance.
PMID: 28126683 [PubMed - as supplied by publisher]
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