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Functional lipidomics: palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.

著者 Lin L , Ding Y , Wang Y , Wang Z , Yin X , Yan G , Zhang L , Yang P , Shen H
Hepatology.2017 Jan 10 ; ():.
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Lipids are essential cellular components and energy sources of living organisms, altered lipid composition is increasingly recognized as a signature of cancer. We performed the lipidomic analysis in a series of hepatocellular carcinoma (HCC) cells and identified over 1700 intact lipids originating from 3 major lipid categories. Comparative lipidomic screening revealed 93 significantly changed lipids and decreased palmitic acyl (C16:0)-containing glycerophospholipids (GPs) were positively associated with metastatic abilities of HCC cells. Furthermore, both in vitro and in vivo experiments designated that C16:0 incubation specifically reduced malignant cell proliferation, impaired cell invasiveness, and suppressed tumor growth in mouse xenograft models. Biochemical experiments demonstrated that C16:0 treatment decreased cell membrane fluidity and limited glucose metabolism. Phosphoproteomics approach further revealed such C16:0 incubation attenuated phosphorylation levels of mTOR and Stat3 pathway proteins. MRM analysis showed 8 declined C16:0-containing lipids out of total 10 changed lipids when compared cancer tissues with adjacent nontumor tissues in a cohort of clinical HCC specimens (P<0.05).
PMID: 28073184 [PubMed - as supplied by publisher]
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