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東日本大震災の地盤沈下 最大30センチ以上隆起 (NHK)

東日本大震災の直後、東北や関東などの沿岸部を中心に最大で1メートル余り沈下した地盤は元に戻る動きが続き、当時と比べて最大で30センチ以上隆起していたことが、国土...

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Qualification of HSQC methods for quantitative composition of heparin and low molecular weight heparins.

著者 Mauri L , Boccardi G , Torri G , Karfunkle M , Macchi E , Muzi L , Keire D , Guerrini M
J Pharm Biomed Anal.2016 Dec 26 ; 136():92-105.
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An NMR HSQC method has recently been proposed for the quantitative determination of the mono- and disaccharide subunits of heparin and low molecular weight heparins (LMWH). The focus of the current study was the validation of this procedure to make the 2D-NMR method suitable for pharmaceutical quality control applications. Pre-validation work investigated the effects of several experimental parameters to assess robustness and to optimize critical factors. Important experimental parameters were pulse sequence selection, equilibration interval between pulse trains and temperature. These observations were needed so that the NMR method was sufficiently understood to enable continuous improvement. A standard validation study on heparin then examined linearity, repeatability, intermediate precision and limits of detection and quantitation; selected validation parameters were also determined for LMWH.
PMID: 28068519 [PubMed - as supplied by publisher]
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