絞り込み

16242

広告

A Rational Approach towards Development of Amorphous Solid Dispersions: Experimental and Computational techniques.

著者 Chakravarty P , Lubach JW , Hau J , Nagapudi K
Int J Pharm.2017 Jan 04 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (4view , 0users)
  • このエントリーをはてなブックマークに追加

Full Text Sources

The purpose of this study was to determine the drug-polymer miscibility of GENE-A, a Genentech molecule, and Hydroxypropyl methylcellulose-acetate succinate (HPMC-AS), a polymer, using computational and experimental approaches. The Flory-Huggins interaction parameter,χ, was obtained by calculating the solubility parameters for GENE-A and HPMC-AS over the temperature range of 25-100°C to obtain the free energy of mixing at different drug loadings (0-100%) using the Materials Studio modeling and simulation platform (thermodynamic approach). Solid-state nuclear magnetic spectroscopy (ssNMR) was used to measure the proton relaxation times for both drug and polymer at different drug loadings (up to 60%) at RT (kinetic approach). Thermodynamically, the drug and polymer were predicted to show favorable mixing as indicated by a negative Gibbs free energy of mixing from 25-100°C. ssNMR showed near identical relaxation times for both drug and polymer in the solid dispersion at RT and 40°C for a period up to 6 months showing phase mixing between the API and polymer on a <10nm scale. Orthogonal computational and experimental approaches indicate phase mixing of the system components.
PMID: 28063904 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード