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WRNIP1: A new guardian of genome integrity at stalled replication forks.

著者 Leuzzi G , Marabitti V , Pichierri P , Franchitto A
Mol Cell Oncol.2016 ; 3(5):e1215777.
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Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.
PMID: 27857978 [PubMed - in process]
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