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Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration.

著者 Zhang S , Chu WC , Lai RC , Lim SK , Hui JH , Toh WS
Osteoarthritis Cartilage.2016 Jul 4 ; ():.
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Clinical and animal studies have demonstrated the efficacy of mesenchymal stem cell (MSC) therapies in cartilage repair. As the efficacy of many MSC-based therapies has been attributed to paracrine secretion, particularly extracellular vesicles/exosomes, we determine here if weekly intra-articular injections of human embryonic MSC-derived exosomes would repair and regenerate osteochondral defects in a rat model.
PMID: 27390028 [PubMed - as supplied by publisher]
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