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アカウミガメ 人工繁殖で3世代目が誕生 和歌山 串本町 (NHK)

アカウミガメの繁殖に取り組んでいる和歌山県串本町の水族館で、人が飼育する環境で3世代目の繁殖に成功しました。水族館によりますと世界で初めてだということです。 串...

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Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice.

著者 Kwon BE , Song JH , Song HH , Kang JW , Hwang SN , Rhee KJ , Shim A , Hong EH , Kim YJ , Jeon SM , Chang SY , Kim DE , Cho S , Ko HJ
PLoS One.2016 ; 11(5):e0155784.
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The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.
PMID: 27195463 [PubMed - in process]
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