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Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease.

著者 Henjum K , Almdahl IS , Årskog V , Minthon L , Hansson O , Fladby T , Nilsson LN
Alzheimers Res Ther.2016 ; 8(1):17.
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Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders. TREM2, a microglial receptor, is involved in innate immunity. A cleaved fragment, soluble TREM2 (sTREM2), is present in the cerebrospinal fluid (CSF).
PMID: 27121148 [PubMed - in process]
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