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High-grade focal areas in low-grade central osteosarcoma: high-grade or still low-grade osteosarcoma?

著者 Righi A , Paioli A , Dei Tos AP , Gambarotti M , Palmerini E , Cesari M , Marchesi E , Donati DM , Picci P , Ferrari S
Clin Sarcoma Res.2015 ; 5():23.
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High-grade foci (grade 3 according to Broder's grading system) are sometimes detected in low-grade (grade 1 and 2) central osteosarcoma. The aim of this study was to retrospectively evaluate the clinical outcome in patients upgraded to high grade (grade 3) after a first diagnosis of low-grade osteosarcoma, following the detection of high-grade areas (grade 3) in the resected specimen.
PMID: 26524981 [PubMed]
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