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Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy.

著者 Bryden L , Nicholson J , Doods H , Pekcec A
Osteoarthritis Cartilage.2015 May 9 ; ():.
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To characterize deficits in burrowing behavior, an ethologically-relevant rodent behavior, in the monosodium-iodoacetate (MIA) rat model of osteoarthritis, and the sensitivity of these deficits to reversal by analgesic drugs of both prototypical and novel mechanisms of action. A second objective was to compare the burrowing assay to a spontaneous locomotor activity assay.
PMID: 25966657 [PubMed - as supplied by publisher]
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