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気管支鏡後に胸部X線写真は全例撮影すべき? (日経BP)

呼吸器内科医の皆さんは、気管支鏡を挿入した後に胸部単純X線写真を撮影していますか? 気管支鏡処置の内容によりけりで、生検を行った症例には全例撮影し、観察や洗浄の...

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Enrichment and separation techniques for large-scale proteomics analysis of the protein post-translational modifications.

著者 Huang J , Wang F , Ye M , Zou H
J Chromatogr A.2014 Nov 6 ; 1372C():1-17.
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Comprehensive analysis of the post-translational modifications (PTMs) on proteins at proteome level is crucial to elucidate the regulatory mechanisms of various biological processes. In the past decades, thanks to the development of specific PTM enrichment techniques and efficient multidimensional liquid chromatography (LC) separation strategy, the identification of protein PTMs have made tremendous progress. A huge number of modification sites for some major protein PTMs have been identified by proteomics analysis. In this review, we first introduced the recent progresses of PTM enrichment methods for the analysis of several major PTMs including phosphorylation, glycosylation, ubiquitination, acetylation, methylation, and oxidation/reduction status. We then briefly summarized the challenges for PTM enrichment. Finally, we introduced the fractionation and separation techniques for efficient separation of PTM peptides in large-scale PTM analysis.
PMID: 25465002 [PubMed - as supplied by publisher]
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