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Determinants Of Oral corticosteroid Responsiveness in Wheezing Asthmatic Youth (DOORWAY): protocol for a prospective multicentre cohort study of children with acute moderate-to-severe asthma exacerbations.

著者 Ducharme FM , Zemek R , Gravel J , Chalut D , Poonai N , Laberge S , Quach C , Krajinovic M , Guimont C , Lemière C , Guertin MC
BMJ Open.2014 ; 4(4):e004699.
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Oral corticosteroids are the cornerstone of acute asthma management in the emergency department. Recent evidence has raised doubts about the efficacy of this treatment in preschool-aged children with viral-induced wheezing and in smoking adults. The aims of the study were to: (1) document the magnitude of response to oral corticosteroids in children presenting to the emergency department with moderate or severe asthma; (2) quantify potential determinants of response to corticosteroids and (3) explore the role of gene polymorphisms associated with the responsiveness to corticosteroids.
PMID: 24710133 [PubMed]
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