Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children.
, Ducharme FM
Evelina Chidlren's Hospital, St Thomas? Hospital, Westminster Bridge Road, London, UK, SE1 7EH.
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There are several treatment options for managing acute asthma exacerbations (sustained worsening of symptoms that do not subside with regular treatment and require a change in management). Guidelines advocate the use of inhaled short acting beta2-agonists (SABAs) in children experiencing an asthma exacerbation. Anticholinergic agents, such as ipratropium bromide and atropine sulfate, have a slower onset of action and weaker bronchodilating effect, but may specifically relieve cholinergic bronchomotor tone and decrease mucosal edema and secretions. Therefore, the combination of inhaled anticholinergics with SABAs may yield enhanced and prolonged bronchodilation.
PMID: 23966133 [PubMed - as supplied by publisher]