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The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study.

著者 Panoutsopoulou K , Metrustry S , Doherty SA , Laslett LL , Maciewicz RA , Hart DJ , Zhang W , Muir KR , Wheeler M , Cooper C , Spector TD , Cicuttini FM , Jones G , Arden NK , Doherty M , Zeggini E , Valdes AM ,
Ann Rheum Dis.2013 Aug 6 ; ():.
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Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We examined the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls incorporating body mass index (BMI) information.
PMID: 23921993 [PubMed - as supplied by publisher]
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