絞り込み

17751

広告

Linkage disequilibrium of the IS629 insertion among different clades of enterohemorrhagic Escherichia coli O157:H7/H- strains.

著者 Hirai S , Yokoyama E , Yamamoto T
Infect Genet Evol.2013 May 14 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Division of Bacteriology, Chiba Prefectural Institute of Public Health, Chiba, Japan; Department of Microbiology and Molecular Genetics, Graduate School of Pharmaceutical Science, Chiba University. Electronic address: s.hri10@pref.chiba.lg.jp.

スターを付ける スターを付ける     (135view , 0users)

Full Text Sources

Research Materials

The distribution of insertion sequence (IS) 629 was investigated among enterohemorrhagic Escherichia coli O157:H7/H- (O157) strains in different clades. Minimum spanning tree analysis showed that most strains in each clade clustered in a separate branch, indicating biased distribution of the IS629 insertion in different clades. The standardized index of association of the IS629 distribution data showed linkage disequilibrium in the strains in every clade, indicating that IS629 distribution data could be used for population genetic analysis. For this population genetic analysis, the ΦPT value, an analogue of Fst, was calculated and indicated that clade 7 strains could be split into two clades based on their lineages. The degree of pairwise linkage disequilibrium was quite different among these two groups. The clade 7 split was in agreement with the model of O157 paraphyletic evolution and a new designation of the lineage II clades was proposed. The prevalence of strains with an IS629 insertion in certain loci was significantly different in different clades. Some of these significant differences were in loci in strains in branches of clades that were close in the O157 phylogenetic model, suggesting that IS629 insertion/deletion was not directly related to the divergence of O157 clades.
PMID: 23684793 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード