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Preoperative Diagnosis of Orbital Cavernous Hemangioma: A 99mTc-RBC SPECT Study.

著者 Burroni L , Borsari G , Pichierri P , Polito E , Toscano O , Grassetto G , Al-Nahhas A , Rubello D , Vattimo AG
Clin Nucl Med.2012 Nov ; 37(11):1041-1046.
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From the Departments of *Nuclear Medicine and †Ophthalmology, University of Siena, Santa Maria alle Scotte Hospital, Siena; ‡Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy and §Department of Nuclear Medicine, Hammer

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PURPOSE: This study aimed to describe Tc-labeled RBC scintigraphy as a diagnostic method for orbital cavernous hemangiomas and to evaluate this diagnostic tool according to surgical outcomes. METHODS: Fifty-five patients with clinical and radiological (US, CT, and/or MRI) suspicion of unilateral cavernous hemangioma of the orbit underwent Tc-RBC SPECT study.Qualitative and semiquantitative evaluations were performed, and results were statistically analyzed. RESULTS: SPECT images showed focal uptake in the orbital mass in 36 of 55 patients. Nineteen patients had a negative scintigraphic pattern, with concordance of early and late absence of uptake of Tc-RBC.Our procedure showed 100% sensitivity and 88.9% specificity for the diagnosis of orbital cavernous hemangioma, with a positive predictive value of 90.9% and a negative predictive value of 100%. CONCLUSIONS: Tc-RBC imaging is safe, easy to perform, and highly accurate in providing adequate clinical and surgical management. As a noninvasive and highly specific method for diagnosing orbital hemangioma, Tc-RBC scintigraphy can avoid more invasive imaging or biopsy.
PMID: 23047756 [PubMed - as supplied by publisher]
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