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京大霊長類研の教授ら4人 5億円余を不正支出 大学が報告書 (NHK)

サルの研究で世界的に有名な京都大学霊長類研究所の教授ら4人が、研究費5億円余りを不正に支出していたとする調査報告書を京都大学がまとめたことが分かりました。 研究...

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  3. 海底の岩、人間の腸内並み微生物 (デイリ...
  4. 新型コロナウイルス感染症の患者等の発生に...

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Characteristics of Oral Mucosal Events Related to Bevacizumab Treatment.

著者 Gavrilovic IT , Balagula Y , Rosen AC , Ramaswamy V , Dickler MN , Dunkel IJ , Lacouture ME
Oncologist.2012 Jan 26 ; ():.
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Department of Neurology.

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AbstractBackground. Bevacizumab, a monoclonal antibody targeting a vascular endothelial growth factor (VEGF) protein, has been reported to induce mucosal toxicities. However, the clinical characteristics of these particular toxicities have not been well characterized. We aimed at providing a detailed clinical description of signs and symptoms limited to the tongue mucosa in patients treated with bevacizumab.Methods. A retrospective review of medical records and clinical photographs was performed with specific attention to clinical presentation, evolution, associated symptoms, concomitant medications, and treatment methods.Results. In total, four patients presented to the dermatology service with clinical findings characterized by multifocal, erythematous circinate and serpiginous erosions on the dorsal tongue surrounded by white hyperkeratotic rims that were temporally related to bevacizumab therapy. Associated increased sensitivity to spicy foods was frequently observed.Conclusion. These characteristic clinical findings are consistent with geographic tongue. However, large prospective evaluations are necessary to confirm this potential relationship. If bevacizumab is indeed associated with geographic tongue, increased awareness may result in improved reporting and characterization of this particular adverse event.
PMID: 22282905 [PubMed - as supplied by publisher]
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