絞り込み

16645

広告

読書の価値を学んだ体験 - すごい人研究所

まだまだ落ち込むことも『ダメだなぁ』と思うこともありますが、ここ1、2年で、読書を通して、大きく成長をすることができました。 読書について考え直すきっかけをくだ...

  1. 肌本来のセラミド産生機能を向上、富山大学...
  2. プラごみ解決探るDVD販売 (デイリース...
  3. [医学] ハンチンチンのリン酸化促進剤タ...
  4. 美容成分プロテオグリカン、脂質異常にも予...

ニュース一覧

The RNase III enzyme Dicer is essential for germinal center B-cell formation.

著者 Xu S , Guo K , Zeng Q , Huo J , Lam KP
Blood.2011 Nov 23 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Bioprocessing Technology Institute, Agency for Science, Technology and Research (A-STAR), Singapore;

スターを付ける スターを付ける     (9,125view , 2,097users)

Full Text Sources

Miscellaneous

Molecular Biology Databases

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and are important for pre-B and follicular B lymphopoiesis as demonstrated respectively, by mb-1-Cre- and cd19-Cre-mediated deletion of Dicer, the RNase III enzyme critical for generating mature miRNAs. To explore the role of miRNAs in B cell terminal differentiation, we use Aicda-Cre to specifically delete Dicer in activated B cells where activation-induced cytidine deaminase (AID) is highly expressed. We demonstrate that mutant mice fail to produce high-affinity class-switched antibodies and generate memory B and long-lived plasma cells (PCs) upon immunization with a T cell-dependent antigen. More importantly, germinal center (GC) B cell formation is drastically compromised in the absence of Dicer, as a result of defects in cell proliferation and survival. Dicer-deficient GC B cells express higher levels of cell cycle inhibitor genes and proapoptotic protein Bim. Ablation of Bim could partially rescue the defect in GC B cell formation in Dicer-deficient mice. Taken together, our data suggest that Dicer and likely, miRNAs are critical for GC B cell formation during B cell terminal differentiation.
PMID: 22117047 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード